We have developed multiple spheroid- and microtissue-based in vitro models to study the growth, repair, and regeneration of human tissues. Particular attention has been paid to the musculoskeletal system and adult mesenchymal stem cells, but our work has also touched on other targets including neurological and tumor models. Outside of these tissue engineering efforts, we have focused on implementing the hyper-compliant microparticle (HCMP) technology developed in the lab for multiple drug delivery applications. Other health-related applications include the development of novel diagnostic tools, specifically cell-like calibration particles and mechanocytometers.