Institute for Biology, Engineering and Medicine (I-BEAM)

Impactful Research

Impactful, translational research at the interface of engineering, biology, and medicine.

Our researchers bridge the gap between clinical and basic research, and innovate translational solutions through interactions with Brown's affiliated hospitals, including the Rhode Island Hospital, Providence Veterans Affairs Healthcare, Butler Hospital, and Miriam Hospital. 

Our researchers are...

  • Developing approaches that detect, prevent, and treat antimicrobial resistant infections, aiming to improve the use of existing and new therapeutics, lower dependence on antimicrobial therapeutics, and reducing the development and spread of infectious disease
  • Restoring mobility, sensation, and communication to those with neurological injury and disease
  • Improving the efficiency of immune cell targeting and activation through engineered nucleic acids to treat cancer
  • Treating heart disease and heart failure with personalized, engineered tissues
  • Developing next-generation microfluidic-based diagnostic platforms
  • And much more!

Research Areas

Brown is at the forefront of neuroengineering and neurotechnology development to restore mobility, sensation, and communication
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Research Highlights

The research team is led by Dr. Beveridge, alongside I-BEAM member Dr. Braden Fleming, PhD, and Brown University Health investigators Dr. Brett Owens, MD, and Janine Molino, PhD, and collaborator Dr. Payam Zandiyeh, PhD, at the University of Texas Health.

Voltron is a tool that emits light bright enough for microscopes to reliably and precisely capture video of action potentials, which happen at millisecond-timescales. Voltron and Voltron 2 can not only effectively detect signals but do so for up to an hour at a time – much longer than with previous tools. For these reasons, the sensors are a breakthrough and provide an alternative to traditional electrode recordings. 

Our research began with a breakthrough in tracking brain microvascular changes in mice using advanced optical imaging techniques. We developed a suite of methods leveraging optical coherence tomography (OCT) to monitor vascular structure, blood flow, and network topology in the aging brain. 

As an electrical/computer engineer and neuroscientist, a primary focus of my work, with Dr. Leigh Hochberg, is developing the BrainGate intracortical neural interface system. 

Breast milk is the ideal nutrition for infants. However, challenges like pain and low milk flow often prevent women from
breastfeeding for the recommended six months. Our long-term goal is to inform clinical techniques to alleviate
common issues impeding breastfeeding, support efforts to reduce reliance on formula, and improve maternal-infant health. The research team is led by Dr. Martinez Wilhelmus. 

The goal in the Nurmikko Lab is to engineer a system of spatially distributed wireless microchips implanted in the brain cortex, each microchip capable of neural recording and electrical stimulation, to add new capabilities to closed-loop adaptive wireless brain-computer interfaces (BCI). 

The lubricin (rhPRG4) biosimilar he co-created is poised to be commercialized. In the coming years RCT’s with this molecule will come to fruition in interstitial cystitis, prevention of post-surgical adhesions and in traumatic brain injury and systemic inflammatory response syndrome by virtue of its blockade of receptors of innate immunity and its profound anti-inflammatory activity. These indications are being pursued by Lubris, LLC a startup co-founded by Gregory Jay MD-PhD. 

The ability to accurately measure musculoskeletal kinematics is necessary to advance our understanding of normal joint function, the changes associated with musculoskeletal diseases, the effects of treatment, and results of treatment refinement. 

Our research focuses on developing a next-generation retinal prosthesis using plasmonic nanorods and near-infrared (NIR) light to restore vision in individuals with degenerative eye diseases such as age-related macular degeneration and retinitis pigmentosa.

The Intelligent Spine Interface (ISI) research program aims to bridge the gap in spinal cord injury through integration of advanced AI/ML strategies, state-of-the-art electronics, and advanced neural interfaces.

This research explores the development of biodegradable hydrogels for targeted drug delivery in chordoma therapy, aiming to enhance treatment efficacy while minimizing systemic toxicity.