We develop controlled and localized drug delivery systems using hydrogels, thin films, and nano- and micro-particles (e.g., self-assembled and polymeric) for a range of clinical applications. We are specifically interested in developing targeted microbe-responsive materials to combat drug resistant bacteria and fungi. Additionally, we develop therapeutic delivery systems and materials that promote specific stem cell behaviors for applications in regenerative medicine and infection treatment. Through this work, we study how the physicochemical properties of the materials we develop influence their functional behavior (e.g., degradation, drug release, targeting).