At present, activity-based therapies are the only medical practices that can be used to enhance recovery after spinal cord injury (SCI). However, the most affected patients, who fail to produce active movements voluntarily, experience minimal benefits from such therapies. Several studies have now shown that spinal cord stimulation delivered at the right time can enhance a physical therapy rehabilitation program significantly, leading to restoration of volitional walking (when the stimulator is on). We therefore propose a bi-directional tool for sensing and stimulating to bridge a gap in the spinal cord, ‘reconnecting’ patches of eloquent nervous system tissue. The Intelligent Spine Interface (ISI) will be capable of reading and writing simultaneously to, and from, the human spinal cord both above, and below, the site of SCI. The ISI will interpret neural information from above a spinal cord lesion and transfer that information, via state-of-the-art artificial neural network-based interpreters, to sites below the lesion and restore volitional control of the lower limb. We will focus our therapeutic demonstrations on the restoration of bi-directional sensing and control of the legs and voluntary locomotion. The proposed technology is agnostic to the level of the spinal lesion and has far greater number of sites (electrodes) to interact with the nervous system, thus making the therapeutic potential far greater than current technologies.