Research Projects
The lubricin (rhPRG4) biosimilar he co-created is poised to be commercialized. In the coming years RCT’s with this molecule will come to fruition in interstitial cystitis, prevention of post-surgical adhesions and in traumatic brain injury and systemic inflammatory response syndrome by virtue of its blockade of receptors of innate immunity and its profound anti-inflammatory activity. These indications are being pursued by Lubris, LLC a startup co-founded by Gregory Jay MD-PhD.
Gregory Jay MD-PhD is a biomedical engineer and emergency medicine physician who is a professor in the School of Engineering (Research) and the Departments of Emergency Medicine, Medicine and Orthopedics. He clinically practices at Rhode Island Hospital. He has spent over 30 years working on a lubricating glycoprotein called lubricin which is down regulated following joint trauma and may increase the risk of future osteoarthritis and is also being harnessed to treat a number of unmet needs. His preclinical studies offer promising results in a new Sports Medicine paradigm to prevent post-traumatic arthritis and in other areas including: prevention of peritoneal adhesions, dry eye disease/Sjogren’s syndrome, and acute gout. These are just some of the 200 papers and many presentations he has authored including 13 issued patents.
Dr. Jay served as Vice Chair for Research in the Brown Department of Emergency Medicine from 2006 to 2022. His clinical research has been focused on resuscitation and biomedical monitoring which has also generated new technologies which have been licensed. He is the co-founder of the RIH Medical Simulation Lab which was founded in 2002 as the first medical simulation center dedicated to EM Simulation and Teamwork Training. Dr. Jay has been a licensed amateur radio operator since 1976.
